Encapsulation of Probiotic Bacteria for Human Use

One of the problems with the administration of probiotic bacteria in drinks or yogurts is that most of the bacteria get rapidly destroyed in the stomach which is highly acidic, and thus never make it to the small intesting where thy are required.

Bac-in-a-Box® is used to encapsulate millions of probiotic bacteria per capsule which are then protected from the acid conditions in the stomach but get released in the small intestine.

Further, bacteria encapsulated in Bac-in-a-Box® can be freeze dried and then stored for long periods at ambient temperature without degradation, making it easy to transport the bacteria without a cold-chain.

To demonstrate the use of Bac-in-a-Box® technology, we have for instance shown that encapsulated probiotic bacteria (lactobacillus acidophilus or johnsonii) will survive exposure to pH2 for 2 hours  with only a 5% reduction in number of live bacteria, whilst unencapsulated bacteria are non-detactable after this time.

Advantages of encapsulation of probiotic bacteria using Bac-in-a-Box include: 

Advantages of encapsulation of probiotic bacteria using Bac-in-a-Box include:

  • Acid protection whilst crossing the stomach
  • Release in small intestine
  • Stable at ambient temperature after freeze drying
  • Rehydrate well from freeze dried form