SCIENTIFIC PUBLICATIONS

Our company’s bio-encapsulation technology and its applications have been published in numerous peer-reviewed, well-respected scientific journals. To access the articles for further information, please click on the links below.

All articles are linked to original article or PubMed where available.

If you are interested in re-prints of any articles, please contact information@austrianova.com with the details.

Semipermeable Cellulose Beads Allow Selective and Continuous Release of Small Extracellular Vesicles (sEV) From Encapsulated Cells

Zavala, G., Ramos, M.-P., Figueroa-Valdés, A. I., Cisternas, P., Wyneken, U., Hernández, M., Toa, P., Salmons, B., Dangerfield, J., Gunzburg, W. H., & Khoury, M. (2020). Semipermeable Cellulose Beads Allow Selective and Continuous Release of Small Extracellular Vesicles (sEV) From Encapsulated Cells. Frontiers in Pharmacology, 11. https://doi.org/10.3389/fphar.2020.

Release characteristics of cellulose sulphate capsules and production of
cytokines from encapsulated cells

Salmons, B. and Gunzburg, W.H. (2018) Release characteristics of cellulose sulphate capsules and production of cytokines from encapsulated cells. International Journal of Pharmaceutics 548,15-22

Encapsulation of insulin producing cells for diabetes treatment using alginate and cellulose sulphate as bioencapsulation polymers: current status

Salmons, B., Brandtner, E-M., Dangerfield, J.A. and Gunzburg, W.H. (2014) Encapsulation of insulin producing cells for diabetes treatment using alginate and cellulose sulphate as bioencapsulation polymers: current status.  Diabetes Research and Treatment 1, 1-7.

Localisation of stem cell and other cell therapies using cell-in-a-box™ for microenvironment containment in patients: a clinically proven enabling cell encapsulation technology

Salmons, B., Dangerfield, J.,  Tan, W.J.,  Toa, P., Pawa, R.,  Aung, M.M., Read, E.,  Gunzburg, W.H., (2014) Localisation of stem cell and other cell therapies using cell-in-a-box™ for microenvironment containment in patients: a clinically proven enabling cell encapsulation technology. Cytotherapy, Vol. 16, Issue 4, April 2014, page S37.

Suicide gene for cancer therapy.

Salmons, B. and Gunzburg, W.H.(2012) Suicide gene for cancer therapy. BioSpectrum Asia Ed., Vol. 7, Issue 15, August 15, pages 15-19.

A method for protecting therapeutic cells and microenvironment containment in patients for gene and cell therapies: a clinically proven enabling cell encapsulation technology

Salmons, B., Dangerfield, J.A., Brandtner, E.M., Toa, P., Tan, W Jin and Gunzburg, W.H. (2010) A method for protecting therapeutic cells and microenvironment containment in patients for gene and cell therapies: a clinically proven enabling cell encapsulation technology. Human Gene Therapy 21 1476-1477

Singapore R&D and Globetrotting

Lear, M.J., Salmons, B., Gunzburg, W.H., and Dangerfield, J. (2009) Singapore R&D and globetrotting. Biotechnology Journal 4, 179-85

Therapeutic application of cell microencapsulation in cancer. In: Therapeutic Applications of Cell Microencapsulation.

Salmons, B. and Gunzburg, W.H. (2009) Therapeutic application of cell microencapsulation in cancer. In: Therapeutic Applications of Cell Microencapsulation. Eds: J.L. Pedraz and G. Orive. Landes Bioscience publishing. in press

Cryopreservation of Insulin-Producing Cells Microencapsulated in Sodium Cellulose Sulfate

Stiegler, P.B., Stadlbauer, V., Schaffellner, S., Halwachs, G., Lackner, C., Hauser, O., Iberer, F. and Tscheliessnigg, K. (2006) Cryopreservation of insulin-producing cells microencapsulated in sodium cellulose sulfate. Transplantation Procedures 38, 3026-30

Combined therapy of experimental pancreatic cancer with CYP2B1 producing cells: low-dose ifosfamide and local tumor irradiation

Ryschich, E., Jesnowski, R., Ringel, J., Harms, W., Fabian, O.V., Saller, R., Schrewe, M., Engel, A., Schmidt, J. and Löhr, M. (2005) Combined therapy of experimental pancreatic cancer with CYP2B1 producing cells: low-dose ifosfamide and local tumor irradiation. International Journal of Cancer 113, 649-53

Disease Progression and Carcinogenesis in the Gastrointestinal Tract

Löhr, M., Hummel, F. Günzburg, W.H. and Salmons, B. (2003) Experimental treatment of pancreatic cancer. Disease Progression and Carcinogenesis in the Gastrointestinal Tract. Eds. Galle, P.R., Gerken, G., Schmidt, W.E. and  Wiedenmann, B. Kluwer Academic Publishers, Dordrecht, The Netherlands

Combination Suicide Gene Therapy

Uckert, W., Salmons, B., Beltinger, C., Günzburg, W.H. and Kammertöns, T. (2003) Combination suicide gene therapy. Methods in Molecular Medicine 90, 345-35

Microencapsulated, CYP2B1-transfected Cells Activating Ifosfamide at the Site of the Tumor: The Magic Bullets of the 21st Century

Lohr, M., Hummel, F., Faulmann, G., Ringel, J., Saller, R., Hain, J., Günzburg, W.H. and Salmons, B. (2002) Microencapsulated, CYP2B1-transfected cells activating ifosfamide at the site of the tumor: the magic bullets of the 21st century. Cancer Chemotherapy and Pharmacology 49, suppl.1 21-24

In Vivo Perivascular Implantation of Encapsulated Packaging Cells for Prolonged Retroviral Gene Transfer

Löhr, J.M., Hoffmeyer, A., Kröger, J-C., Freund, M., Hain, J., Holle, A., Karle, P., Knöfel, W.T., Liebe, S., Müller, P., Nizze, H., Renner, M., Saller, R.M., Wagner, T., Hauenstein, K. Günzburg, W.H., and Salmons, B. (2001) Microencapsulated cell mediated therapy of inoperable pancreatic carcinoma. Lancet 357, 1591-1592  (Click on the following link to read a full-version of the article lancet357,1591-1592 )

Immunotherapy of a Viral Disease by in Vivo Production of Therapeutic Monoclonal Antibodies

Pelegrin, M., Marin, M., Oates, A., Noël, D., Saller, R., Salmons, B. and Piechaczyk, M. (2000) Immunotherapy of a viral disease by in vivo production of therapeutic monoclonal antibodies. Human Gene Therapy 11, 1407-1416

Injection of Encapsulated Cells Producing an Ifosfamide-Activating Cytochrome P450 for Targeted Chemotherapy to Pancreatic Tumors

Muller, P., Jesnowski, R., Karle, P., Renz, R., Saller, R., Stein, H., Puschel, K., von Rombs, K., Nizze, H., Liebe, S., Wagner, T., Günzburg, W.H., Salmons, B., Lohr, M. (1999) Injection of encapsulated cells producing an ifosfamide-activating cytochrome P450 for targeted chemotherapy to pancreatic tumors. Annals of New York Academy of Science 880, 337-351

Cell Therapy Using Microencapsulated 293 Cells Transfected With a Gene Construct Expressing CYP2B1, an Ifosfamide Converting Enzyme, Instilled Intra-Arterially in Patients With Advanced-Stage Pancreatic Carcinoma: A Phase I/II Study

Löhr, J.M., Bago, Z.T., Bergmeister, H., Ceijka, M., Freund, M., Gelbmann, W., Günzburg, W.H., Hain, J., Hauenstein, K., Henniger, W., Hoffmeyer, A., Karle, P., Kröger, J-C., Liebe, S., Losert, U., Probst, A., Renner, M., Renz, R., Saller, R., Salmons, B., Schuh, M., Wagner, T. and Walter, I. (1999) Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting enzyme, instilled intra-arterially in patients with advanced stage pancreatic carcinoma: phase I/II study. Journal of Molecular Medicine. 77, 393-398

Intratumoral Injection of Encapsulated Cells Producing an Oxazaphosphorine Activating Cytochrome P450 for Targeted Chemotherapy

Karle, P., Müller, P., Renz, R., Jesnowski, R., Saller, R.M., von Rombs, K., Nizze, H., Liebe, S., Günzburg, W.H., Salmons, B and Löhr, M. (1998) Intratumour injection of encapsulated cells producing an ifosfamide activating cytochrome P450 for targeted chemotherapy. Adv. Exp. Med. Biol. 451, 97-106

Delivery of probiotics efficiently to the intestine: the acid test

Salmons, B., Dangerfield, J. and Gunzburg, W.H. (2020) Delivery of probiotics efficiently to the intestine: the acid test. NuFFooDS Spectrum Asia, 15th April 2020

https://www.nuffoodsspectrum.asia/analysis/54/1525/delivery-of-probiotics-efficiently-to-the-intestine-the-acid-test.html

A game-changing live cell encapsulation technology for enabling allogenic cell therapies and delivery of probiotics to the gut

Dangerfield, J.A., Read, E., Salmons, B. and Gunzburg, W.H. (2018) A game-changing live cell encapsulation technology for enabling allogenic cell therapies and delivery of probiotics to the gut. Regenerative Research 7(1), 40

Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy andare safe and efficacious: data from two clinical trials in pancreatic cancer

Löhr, J. M.; Haas, Stephan L.; Kröger, Jens C.; Friess, Helmut M.; Höft, Raimund; Goretzki, Peter E.; Peschel, C.; Schweigert, M.; Salmons, B.; Gunzburg, W. H. (2014). Encapsulated Cells Expressing a Chemotherapeutic Activating Enzyme Allow the Targeting of Subtoxic Chemotherapy and Are Safe and Efficacious: Data from Two Clinical Trials in Pancreatic Cancer.Pharmaceutics 6, no. 3: 447-466.

Chapter 3: The Diversity of Uses for Cellulose Sulphate Encapsulation

Dangerfield, J.A., Salmons, B., Corteling, R., Abastado, J-P., Sinden, J., Gunzburg, W.H. and Brandtner, E.M., (2013) Chapter 3: The Diversity of Uses for Cellulose Sulphate Encapsulation. in E-Book: “Bioencapsulation of living cells for diverse medical applications”, Brandtner E.M., Dangerfield J.A. (Eds.), Bentham Science Publishers, June 2013, pages 70-92.

Evaluation of a Gene-Directed Enzyme-Product Therapy (GDEPT) in Human Pancreatic Tumor Cells and Their Use as In Vivo Models for Pancreatic Cancer

Hlavaty J., Petznek H., Holzmueller H., Url A., Jandl G., Berger, A., Salmons, B., Gunzburg, W.H., and M., Renner (2012) Evaluation of a Gene-Directed Enzyme-Product Therapy (GDEPT) in Human Pancreatic Tumor Cells and Their Use as In Vivo Models for Pancreatic Cancer. PLoS One, July 16;7(7):1-9.e40611. doi:10.1371/journal.pone.0040611

Magnetic field-controlled gene expression in encapsulated cells

Ortner, V., Kaspar, C., Halter, C. Toellner, L., Mykhaylyk, O., Walzer, J., Gunzburg, W.H., Dangerfield, J.A., Hohenadl, C. T. Czerny, (2010) Magnetic field-controlled gene expression in encapsulated cells. Journal of Controlled Release, Mar 28;158(3):424-32.

Cell microencapsulation in cancer therapy. In: The bioartificial pancreas and other biohybrid therapies

Salmons, B., Hauser, O., Gunzburg W.H. and Tabotta W. (2009) Cell microencapsulation in cancer therapy. In: The bioartificial pancreas and other biohybrid therapies. Eds: Pierre Hallé, Paul de Vos and Lawrence Rosenberg. Research Signpost publishing. pp595-606

Targeted Intraabdominal Chemotherapy For Peritoneal Carcinomatosis

Samel, S. and Löhr, M. (2007) Targeted intra-abdominal chemotherapy for peritoneal carcinomatosis. Cancer Treatment and Research 134, 469-82

Use of Cell Therapy as a Means of Targeting Chemotherapy to Inoperable Pancreatic Cancer

Günzburg, W.H. and Salmons, B. (2005) Cell and gene therapy to improve cancer treatment. Acta Biochimica Polonica 52, 601-607

Safety, feasibility and clinical benefit of localized chemotherapy using microencapsulated cells for inoperable pancreatic carcinoma in a phase I/II trial

Löhr, J.M., Kröger, J-C., Hoffmeyer, A., Freund, M., Hain, J., Holle, A., Knöfel, W.T., Liebe, S., Nizze, H., Renner, M., Saller, R., Karle, P., Müller, P., Wagner, T., Hauenstein, K., Salmons, B. and Günzburg, W.H. (2003) Safety, feasibility and clinical benefit of localized chemotherapy using microencapsulated cells for inoperable pancreatic carcinoma in a phase I/II trial. Cancer Therapy 1, 121-131

Treatment of Inoperable Pancreatic Carcinoma Using a Cell-Based Local Chemotherapy: Results of a Phase I/II Clinical Trial

Salmons, B., Löhr, M. and Günzburg, W.H. (2003) Treatment of inoperable pancreatic carcinoma using a cell based local chemotherapy: results of a phase I/II clinical trial. Journal of Gastroenterology 38 (Suppl XV), 78-84

Encapsulated Cells Producing Retroviral Vectors for in Vivo Gene Transfer

Saller, R.M., Indraccolo, S., Coppola, V., Esposito, G., Stange, J., Mitzner, S., Heinzmann, U., Amadori, A., Salmons, B. and Günzburg, W.H. (2002) Encapsulated cells producing retroviral vectors for in vivo gene transfer. Journal of  Gene Medicine 4, 150-160

Löhr, M., Saller, R.M., Salmons, B. and Günzburg, W.H. (2002).Methods in Enzymology 346, 603-618

New strategies for the gene therapy of solid and metastatic tumours

Günzburg, W.H., Renner, M. and Salmons, B. (2000) New strategies for the gene therapy of solid and metastatic tumours. Annales Universitatis Mariae Curie-Sklodowska: Sectio DD Medicina Veterinaria vol. LV/A pp9-14

Combined Chemotherapy of Murine Mammary Tumors by Local Activation of the Prodrugs Ifosfamide and 5-fluorocytosine

Kammertöns, T., Gelbmann, W., Karle, P., Saller, R., Salmons, B., Günzburg, W.H. and Uckert, W. (2000) Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine. Cancer Gene Therapy 7, 629-636

Intraarterial Instillation of Microencapsulated Cells in the Pancreatic Arteries in Pig

Kröger, J.C., Bergmeister, H., Hoffmeyer, A., Ceijna, M., Karle, P., Saller, R., Schwendenwein, I., von Rombs, K., Liebe, S., Günzburg, W.H., Salmons, B., Hauenstein, K-H., Losert, U. and Löhr, M. (1999) Intra-arterial instillation of microencapsulated cells in the pancreatic arteries in pig. Annu. N. Y. Acad. Sci. 880, 374-378

Development of Cellulose Sulfate-Based Polyelectrolyte Complex Microcapsules for Medical Applications

Dautzenberg, H., Schuldt, U., Grasnick, G., Karle, P., Müller, P., Löhr, M., Pelegrin, M., Piechaczyk, M., von Rombs, K., Günzburg, W.H., Salmons, B. and Saller, R.M. (1999) Development of cellulose sulphate based polyelectrolyte complex microcapsules for medical applications. (Bioartificial Organs II: Technology, Medicine & Materials. Eds. Hunkeler, D., Prokop, A., Cherrrington, A.D., Rajotte, R. and Sefton, M.) Annu. N.Y. Acad. Sci. 875, 46-63

Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome

Löhr, M.,  Müller, P., Karle, P., Stange, J., Mitzner, S., Jesnowski, R., Nizze, H., Nebe, B., Liebe, S., Salmons, B. and Günzburg, W.H. (1998) Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450. Gene Therapy 5, 1070-1078

Treating diseases by redressing the microbiome balance

Salmons, B. and Gunzburg, W.H. (2019) Treating diseases by redressing the microbiome balance. BioSpectrum Asia, 21st February 2019 https://www.biospectrumasia.com/opinion/26/12857/treating-diseases-by-redressing-the-microbiome-balance-.html

Encapsulation enters the Pharma industry mainstream

Salmons, B. and Gunzburg, W.H. (2018) Encapsulation enters the Pharma industry mainstream. BioSpectrum Asia, 9th April 2018.

https://www.biospectrumasia.com/analysis/26/10645/encapsulation-enters-the-pharma-industry-mainstream.html

Phase I/ii clinical trial of encapsulated, cytochrome p450 expressing cells as local activators of cyclophosphamide to treat spontaneous canine tumours

Michałowska M, Winiarczyk S, Adaszek Ł, Łopuszyński W, Grądzki Z, et al. (2014) Phase I/II Clinical Trial of Encapsulated, Cytochrome P450 Expressing Cells as Local Activators of Cyclophosphamide to Treat Spontaneous Canine Tumours. PLoS ONE 9(7): e102061. doi:10.1371/journal.pone.0102061

Inselzellen vor dem Immunangriff schuetzen

Brandtner, E.M., Muendlein, A., Salmons, B. and H. Drexel. (2012) Inselzellen vor dem Immunangriff schuetzen. 40. Jahrestagung der Oesterreichischen Diabetes Gesellschaft, November 2012, pages 6-7.

A novel cell encapsulation mode for delivery of therapeutic antibodies against West Nile Virus infections that maintains steady plasma antibody levels throughout therapy.

Chua, A.J.S., Brandtner, E.M., Dangerfield, J.A., Salmons, B., Gunzburg, W.H. and Ng, M.L. (2010) A novel cell encapsulation mode for delivery of therapeutic antibodies against West Nile Virus infections that maintains steady plasma antibody levels throughout therapy. International Congress on Infectious Diseases (ICID): Abstract 24.010. doi:10.1016/jijid.2010.02

Encapsulated Cells to Focus the Metabolic Activation of Anticancer Drugs

Salmons, B., Brandtner, E.M., Hettrich, K. Wagenknecht, W., Volkert, B., Fischer, S., Dangerfield, J.A. and Gunzburg,W.H. (2010) Encapsulated cells to focus the metabolic activation of anti-cancer drugs. Current Opinion in Molecular Therapeutics 12(4):450-60

Stem Cell Therapies: On Track but Suffer Setback

Gunzburg, W.H. and Salmons, B. (2009) Stem cell therapies: on track but suffer setback. Current Opinion in Molecular Therapeutics 11, 360-363

Xenotransplantation of NaCS microencapsulated porcine islet cells in diabetic rats

Stiegler, P., Stadlbauer, V., Hackl, F., Iberer F., Lackner, C., Hauser, O., Schaffellner, S., Strunk, D., Tscheliessnigg, K.H. (2009) Xenotransplantation of NaCS microencapsulated porcine islet cells in diabetic rats. Organ Biology, 16(1) : 104

Peritoneal Cancer Treatment With CYP2B1 Transfected, Microencapsulated Cells and Ifosfamide

Sahel, S., Keese, M., Lux, A., Jesnowski, R., Prosst, R., Saller, R., Hafner, M., Sturm, J., Post, S. and Löhr, M. (2006) Peritoneal cancer treatment with CYP2B1 transfected, microencapsulated cells and ifosfamide. Cancer Gene Therapy. 13, 65-73

Porcine Islet Cells Microencapsulated in Sodium Cellulose Sulfate

Schaffellner, S., Stadlbauer, V., Stiegler, P., Hauser, O., Halwachs, G., Lackner, C., Iberer, F. and Tscheliessnigg, K.H. (2005) Porcine islet cells microencapsulated in sodium cellulose sulfate. Transplantation Procedures 37, 248-452

Encapsulated, Genetically Modified Cells Producing in Vivo Therapeutics

Hauser, O., Prieschl-Grassauer, E. and Salmons, B. (2004) Encapsulated, genetically modified, cells producing in vivo therapeutics. Current Opinion in Molecular Therapeutics 6, 412-420

Intra-arterial Instillation of Microencapsulated, Ifosfamide-activating Cells in the Pig Pancreas for Chemotherapeutic Targeting

Kröger, J-C., Benz, S., Hoffmeyer, A., Bago, Z., Bergmeister, H., Günzburg, W.H., Karle, P., Klöppel, G., Losert, U., Müller, P., Nizze, H., Obermaier, R., Probst, A., Renner, M., Saller, R., Salmons, B., Schwendenwein, I., von Rombs, K., Wiessner, R., Wagner, T., Hauenstein, K. and Löhr, M. (2003) Intra-arterial Instillation of microencapsulated, ifosfamide activating cells in the pig pancreas for chemotherapeutic targeting. Pancreatology 3, 55-63

A Clinical Protocol for Treatment of Canine Mammary Tumors Using Encapsulated, Cytochrome P450 Synthesizing Cells Activating Cyclophosphamide: A Phase I/II Study

Winiarczyk, S., Gradski, Z., Kosztolich, B., König, G., Günzburg, W.H., Salmons, B. and J. Hain (2002) Treatment of dogs with mammary tumours using encapsulated, cytochrome P450 synthesising cells thereby activating cyclophosphamide. Journal of molecular Medicine 80, 610-614

Novel Treatments and Therapies in Development for Pancreatic Cancer

Günzburg WH, Löhr M, Salmons B. (2002) Novel treatments and therapies in development for pancreatic cancer. Expert Opinion on Investigational Drugs. Jun;11(6):769-86.

Microcapsules as a novel alternative for systemic in vivo delivery of virus vectors

Saller, R.M., Stange J., Mitzner, S., von Rombs, K., Hutzler, P., Dautzenberg, H., Günzburg, W.H. and Salmons, B. (2000) Microcapsules as a novel alternative for systemic in vivo delivery of virus vectors. Minerva Biotecnologica 12, 305-308

Encapsulated antibody-producing cells for long-term passive immunotherapy

Pelegrin, M., Noel, D., Saller, R.M., Salmons, B. and Piechaczyk, M. (1999) Encapsulated antibody-producing cells for long-term passive immunotherapy. Pharmaceutical Technology 23, 46-49 (also BioPharm 12, 32-35)

Characterization of a Human Cell Clone Expressing Cytochrome P450 for Safe Use in Human Somatic Cell Therapy

Günzburg, W.H., Karle, P., Renz, R., Salmons, B. and Renner, M. (1999) Characterisation of a human cell clone expressing cytochrome P450 for safe use in human somatic cell therapy. Annu. N. Y. Acad. Sci. 880, 326-336

In vivo production of therapeutic antibodies by engineered cells for immunotherapy of cancer and viral diseases

Pelegrin, M., Noel, D., Marin, M., Bachrach, E., Saller, R.M., Salmons, B. and Piechaczyk, M. (1999) In vivo production of therapeutic antibodies by engineered cells for immunotherapy of cancer and viral diseases. Gene Ther. Mol. Biol. 3, 167-177

Systemic long-term delivery of antibodies in immunocompetent animals using cellulose sulphate capsules containing antibody-producing cells

Pelegrin, M., Marin, M., Noël, D., Del Rio, M., Saller, R., Stange, J., Mitzner, S., Günzburg, W.H. and Piechaczyk, M. (1998) Systemic long-term delivery of antibodies in immunocompetent animals using cellulose sulphate capsules containing antibody-producing cells. Gene Therapy 5, 828-834