SCIENTIFIC PUBLICATIONS
Our company’s bio-encapsulation technology and its applications have been published in numerous peer-reviewed, well-respected scientific journals. To access the articles for further information, please click on the links below.
All articles are linked to original article or PubMed where available.
If you are interested in re-prints of any articles, please contact query@austrianova.com with the details.
Efficient protection of microorganisms for delivery to the intestinal tract by cellulose sulphate encapsulation.
Gunzburg, WH, Aung, MM, Toa, P, Ng, S, Read, E, Tan, WJ, Brandtner, EM, Dangerfield, J, & Salmons, B (2020). Efficient protection of microorganisms for delivery to the intestinal tract by cellulose sulphate encapsulation.
Microbial Cell Factories 19(1) 216 https://doi.org/10.1186/s12934-020-01465-3
Semipermeable Cellulose Beads Allow Selective and Continuous Release of Small Extracellular Vesicles (sEV) From Encapsulated Cells
Zavala, G., Ramos, M.-P., Figueroa-Valdés, A. I., Cisternas, P., Wyneken, U., Hernández, M., Toa, P., Salmons, B., Dangerfield, J., Gunzburg, W. H., & Khoury, M. (2020). Semipermeable Cellulose Beads Allow Selective and Continuous Release of Small Extracellular Vesicles (sEV) From Encapsulated Cells. Frontiers in Pharmacology, 11. https://doi.org/10.3389/fphar.2020.
Release characteristics of cellulose sulphate capsules and production of
cytokines from encapsulated cells
Salmons, B. and Gunzburg, W.H. (2018) Release characteristics of cellulose sulphate capsules and production of cytokines from encapsulated cells. International Journal of Pharmaceutics 548,15-22
Encapsulation of insulin producing cells for diabetes treatment using alginate and cellulose sulphate as bioencapsulation polymers: current status
Salmons, B., Brandtner, E-M., Dangerfield, J.A. and Gunzburg, W.H. (2014) Encapsulation of insulin producing cells for diabetes treatment using alginate and cellulose sulphate as bioencapsulation polymers: current status. Diabetes Research and Treatment 1, 1-7.
Localisation of stem cell and other cell therapies using cell-in-a-box™ for microenvironment containment in patients: a clinically proven enabling cell encapsulation technology
Salmons, B., Dangerfield, J., Tan, W.J., Toa, P., Pawa, R., Aung, M.M., Read, E., Gunzburg, W.H., (2014) Localisation of stem cell and other cell therapies using cell-in-a-box™ for microenvironment containment in patients: a clinically proven enabling cell encapsulation technology. Cytotherapy, Vol. 16, Issue 4, April 2014, page S37.
Suicide gene for cancer therapy.
Salmons, B. and Gunzburg, W.H.(2012) Suicide gene for cancer therapy. BioSpectrum Asia Ed., Vol. 7, Issue 15, August 15, pages 15-19.
A method for protecting therapeutic cells and microenvironment containment in patients for gene and cell therapies: a clinically proven enabling cell encapsulation technology
Singapore R&D and Globetrotting
Lear, M.J., Salmons, B., Gunzburg, W.H., and Dangerfield, J. (2009) Singapore R&D and globetrotting. Biotechnology Journal 4, 179-85
Therapeutic application of cell microencapsulation in cancer. In: Therapeutic Applications of Cell Microencapsulation.
Salmons, B. and Gunzburg, W.H. (2009) Therapeutic application of cell microencapsulation in cancer. In: Therapeutic Applications of Cell Microencapsulation. Eds: J.L. Pedraz and G. Orive. Landes Bioscience publishing. in press
GMP production of an encapsulated cell therapy product: issues and considerations
Salmons, B., Hauser, O., Gunzburg, W.H. and Tabotta, W. (2007) GMP production of an encapsulated cell therapy product: issues and considerations. BioProcessing Journal 4, 36-43
Disease Progression and Carcinogenesis in the Gastrointestinal Tract
Löhr, M., Hummel, F. Günzburg, W.H. and Salmons, B. (2003) Experimental treatment of pancreatic cancer. Disease Progression and Carcinogenesis in the Gastrointestinal Tract. Eds. Galle, P.R., Gerken, G., Schmidt, W.E. and Wiedenmann, B. Kluwer Academic Publishers, Dordrecht, The Netherlands
Combination Suicide Gene Therapy
Uckert, W., Salmons, B., Beltinger, C., Günzburg, W.H. and Kammertöns, T. (2003) Combination suicide gene therapy. Methods in Molecular Medicine 90, 345-35
Microencapsulated, CYP2B1-transfected Cells Activating Ifosfamide at the Site of the Tumor: The Magic Bullets of the 21st Century
In Vivo Perivascular Implantation of Encapsulated Packaging Cells for Prolonged Retroviral Gene Transfer
Immunotherapy of a Viral Disease by in Vivo Production of Therapeutic Monoclonal Antibodies
Injection of Encapsulated Cells Producing an Ifosfamide-Activating Cytochrome P450 for Targeted Chemotherapy to Pancreatic Tumors
Cell Therapy Using Microencapsulated 293 Cells Transfected With a Gene Construct Expressing CYP2B1, an Ifosfamide Converting Enzyme, Instilled Intra-Arterially in Patients With Advanced-Stage Pancreatic Carcinoma: A Phase I/II Study
Intratumoral Injection of Encapsulated Cells Producing an Oxazaphosphorine Activating Cytochrome P450 for Targeted Chemotherapy
Delivery of probiotics efficiently to the intestine: the acid test
Salmons, B., Dangerfield, J. and Gunzburg, W.H. (2020) Delivery of probiotics efficiently to the intestine: the acid test. NuFFooDS Spectrum Asia, 15th April 2020
https://www.nuffoodsspectrum.asia/analysis/54/1525/delivery-of-probiotics-efficiently-to-the-intestine-the-acid-test.html
A game-changing live cell encapsulation technology for enabling allogenic cell therapies and delivery of probiotics to the gut
Dangerfield, J.A., Read, E., Salmons, B. and Gunzburg, W.H. (2018) A game-changing live cell encapsulation technology for enabling allogenic cell therapies and delivery of probiotics to the gut. Regenerative Research 7(1), 40
Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy andare safe and efficacious: data from two clinical trials in pancreatic cancer
Löhr, J. M.; Haas, Stephan L.; Kröger, Jens C.; Friess, Helmut M.; Höft, Raimund; Goretzki, Peter E.; Peschel, C.; Schweigert, M.; Salmons, B.; Gunzburg, W. H. (2014). Encapsulated Cells Expressing a Chemotherapeutic Activating Enzyme Allow the Targeting of Subtoxic Chemotherapy and Are Safe and Efficacious: Data from Two Clinical Trials in Pancreatic Cancer.Pharmaceutics 6, no. 3: 447-466.
Chapter 3: The Diversity of Uses for Cellulose Sulphate Encapsulation
Dangerfield, J.A., Salmons, B., Corteling, R., Abastado, J-P., Sinden, J., Gunzburg, W.H. and Brandtner, E.M., (2013) Chapter 3: The Diversity of Uses for Cellulose Sulphate Encapsulation. in E-Book: “Bioencapsulation of living cells for diverse medical applications”, Brandtner E.M., Dangerfield J.A. (Eds.), Bentham Science Publishers, June 2013, pages 70-92.
Evaluation of a Gene-Directed Enzyme-Product Therapy (GDEPT) in Human Pancreatic Tumor Cells and Their Use as In Vivo Models for Pancreatic Cancer
Hlavaty J., Petznek H., Holzmueller H., Url A., Jandl G., Berger, A., Salmons, B., Gunzburg, W.H., and M., Renner (2012) Evaluation of a Gene-Directed Enzyme-Product Therapy (GDEPT) in Human Pancreatic Tumor Cells and Their Use as In Vivo Models for Pancreatic Cancer. PLoS One, July 16;7(7):1-9.e40611. doi:10.1371/journal.pone.0040611
Magnetic field-controlled gene expression in encapsulated cells
Ortner, V., Kaspar, C., Halter, C. Toellner, L., Mykhaylyk, O., Walzer, J., Gunzburg, W.H., Dangerfield, J.A., Hohenadl, C. T. Czerny, (2010) Magnetic field-controlled gene expression in encapsulated cells. Journal of Controlled Release, Mar 28;158(3):424-32.
Cell microencapsulation in cancer therapy. In: The bioartificial pancreas and other biohybrid therapies
Salmons, B., Hauser, O., Gunzburg W.H. and Tabotta W. (2009) Cell microencapsulation in cancer therapy. In: The bioartificial pancreas and other biohybrid therapies. Eds: Pierre Hallé, Paul de Vos and Lawrence Rosenberg. Research Signpost publishing. pp595-606
Targeted Intraabdominal Chemotherapy For Peritoneal Carcinomatosis
Samel, S. and Löhr, M. (2007) Targeted intra-abdominal chemotherapy for peritoneal carcinomatosis. Cancer Treatment and Research 134, 469-82
Use of Cell Therapy as a Means of Targeting Chemotherapy to Inoperable Pancreatic Cancer
Safety, feasibility and clinical benefit of localized chemotherapy using microencapsulated cells for inoperable pancreatic carcinoma in a phase I/II trial
Löhr, J.M., Kröger, J-C., Hoffmeyer, A., Freund, M., Hain, J., Holle, A., Knöfel, W.T., Liebe, S., Nizze, H., Renner, M., Saller, R., Karle, P., Müller, P., Wagner, T., Hauenstein, K., Salmons, B. and Günzburg, W.H. (2003) Safety, feasibility and clinical benefit of localized chemotherapy using microencapsulated cells for inoperable pancreatic carcinoma in a phase I/II trial. Cancer Therapy 1, 121-131
Treatment of Inoperable Pancreatic Carcinoma Using a Cell-Based Local Chemotherapy: Results of a Phase I/II Clinical Trial
Salmons, B., Löhr, M. and Günzburg, W.H. (2003) Treatment of inoperable pancreatic carcinoma using a cell based local chemotherapy: results of a phase I/II clinical trial. Journal of Gastroenterology 38 (Suppl XV), 78-84
Encapsulated Cells Producing Retroviral Vectors for in Vivo Gene Transfer
Saller, R.M., Indraccolo, S., Coppola, V., Esposito, G., Stange, J., Mitzner, S., Heinzmann, U., Amadori, A., Salmons, B. and Günzburg, W.H. (2002) Encapsulated cells producing retroviral vectors for in vivo gene transfer. Journal of Gene Medicine 4, 150-160
Löhr, M., Saller, R.M., Salmons, B. and Günzburg, W.H. (2002).Methods in Enzymology 346, 603-618
New strategies for the gene therapy of solid and metastatic tumours
Günzburg, W.H., Renner, M. and Salmons, B. (2000) New strategies for the gene therapy of solid and metastatic tumours. Annales Universitatis Mariae Curie-Sklodowska: Sectio DD Medicina Veterinaria vol. LV/A pp9-14
Combined Chemotherapy of Murine Mammary Tumors by Local Activation of the Prodrugs Ifosfamide and 5-fluorocytosine
Intraarterial Instillation of Microencapsulated Cells in the Pancreatic Arteries in Pig
Development of Cellulose Sulfate-Based Polyelectrolyte Complex Microcapsules for Medical Applications
Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome
Löhr, M., Müller, P., Karle, P., Stange, J., Mitzner, S., Jesnowski, R., Nizze, H., Nebe, B., Liebe, S., Salmons, B. and Günzburg, W.H. (1998) Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450. Gene Therapy 5, 1070-1078
Treating diseases by redressing the microbiome balance
Salmons, B. and Gunzburg, W.H. (2019) Treating diseases by redressing the microbiome balance. BioSpectrum Asia, 21st February 2019 https://www.biospectrumasia.com/opinion/26/12857/treating-diseases-by-redressing-the-microbiome-balance-.html
Encapsulation enters the Pharma industry mainstream
Salmons, B. and Gunzburg, W.H. (2018) Encapsulation enters the Pharma industry mainstream. BioSpectrum Asia, 9th April 2018.
https://www.biospectrumasia.com/analysis/26/10645/encapsulation-enters-the-pharma-industry-mainstream.html
Phase I/ii clinical trial of encapsulated, cytochrome p450 expressing cells as local activators of cyclophosphamide to treat spontaneous canine tumours
Michałowska M, Winiarczyk S, Adaszek Ł, Łopuszyński W, Grądzki Z, et al. (2014) Phase I/II Clinical Trial of Encapsulated, Cytochrome P450 Expressing Cells as Local Activators of Cyclophosphamide to Treat Spontaneous Canine Tumours. PLoS ONE 9(7): e102061. doi:10.1371/journal.pone.0102061
Inselzellen vor dem Immunangriff schuetzen
Brandtner, E.M., Muendlein, A., Salmons, B. and H. Drexel. (2012) Inselzellen vor dem Immunangriff schuetzen. 40. Jahrestagung der Oesterreichischen Diabetes Gesellschaft, November 2012, pages 6-7.
A novel cell encapsulation mode for delivery of therapeutic antibodies against West Nile Virus infections that maintains steady plasma antibody levels throughout therapy.
Chua, A.J.S., Brandtner, E.M., Dangerfield, J.A., Salmons, B., Gunzburg, W.H. and Ng, M.L. (2010) A novel cell encapsulation mode for delivery of therapeutic antibodies against West Nile Virus infections that maintains steady plasma antibody levels throughout therapy. International Congress on Infectious Diseases (ICID): Abstract 24.010. doi:10.1016/jijid.2010.02
Encapsulated Cells to Focus the Metabolic Activation of Anticancer Drugs
Salmons, B., Brandtner, E.M., Hettrich, K. Wagenknecht, W., Volkert, B., Fischer, S., Dangerfield, J.A. and Gunzburg,W.H. (2010) Encapsulated cells to focus the metabolic activation of anti-cancer drugs. Current Opinion in Molecular Therapeutics 12(4):450-60
Stem Cell Therapies: On Track but Suffer Setback
Gunzburg, W.H. and Salmons, B. (2009) Stem cell therapies: on track but suffer setback. Current Opinion in Molecular Therapeutics 11, 360-363
Xenotransplantation of NaCS microencapsulated porcine islet cells in diabetic rats
Stiegler, P., Stadlbauer, V., Hackl, F., Iberer F., Lackner, C., Hauser, O., Schaffellner, S., Strunk, D., Tscheliessnigg, K.H. (2009) Xenotransplantation of NaCS microencapsulated porcine islet cells in diabetic rats. Organ Biology, 16(1) : 104
Peritoneal Cancer Treatment With CYP2B1 Transfected, Microencapsulated Cells and Ifosfamide
Sahel, S., Keese, M., Lux, A., Jesnowski, R., Prosst, R., Saller, R., Hafner, M., Sturm, J., Post, S. and Löhr, M. (2006) Peritoneal cancer treatment with CYP2B1 transfected, microencapsulated cells and ifosfamide. Cancer Gene Therapy. 13, 65-73
Porcine Islet Cells Microencapsulated in Sodium Cellulose Sulfate
Schaffellner, S., Stadlbauer, V., Stiegler, P., Hauser, O., Halwachs, G., Lackner, C., Iberer, F. and Tscheliessnigg, K.H. (2005) Porcine islet cells microencapsulated in sodium cellulose sulfate. Transplantation Procedures 37, 248-452
Encapsulated, Genetically Modified Cells Producing in Vivo Therapeutics
Hauser, O., Prieschl-Grassauer, E. and Salmons, B. (2004) Encapsulated, genetically modified, cells producing in vivo therapeutics. Current Opinion in Molecular Therapeutics 6, 412-420
Intra-arterial Instillation of Microencapsulated, Ifosfamide-activating Cells in the Pig Pancreas for Chemotherapeutic Targeting
Kröger, J-C., Benz, S., Hoffmeyer, A., Bago, Z., Bergmeister, H., Günzburg, W.H., Karle, P., Klöppel, G., Losert, U., Müller, P., Nizze, H., Obermaier, R., Probst, A., Renner, M., Saller, R., Salmons, B., Schwendenwein, I., von Rombs, K., Wiessner, R., Wagner, T., Hauenstein, K. and Löhr, M. (2003) Intra-arterial Instillation of microencapsulated, ifosfamide activating cells in the pig pancreas for chemotherapeutic targeting. Pancreatology 3, 55-63
A Clinical Protocol for Treatment of Canine Mammary Tumors Using Encapsulated, Cytochrome P450 Synthesizing Cells Activating Cyclophosphamide: A Phase I/II Study
Winiarczyk, S., Gradski, Z., Kosztolich, B., König, G., Günzburg, W.H., Salmons, B. and J. Hain (2002) Treatment of dogs with mammary tumours using encapsulated, cytochrome P450 synthesising cells thereby activating cyclophosphamide. Journal of molecular Medicine 80, 610-614
Novel Treatments and Therapies in Development for Pancreatic Cancer
Günzburg WH, Löhr M, Salmons B. (2002) Novel treatments and therapies in development for pancreatic cancer. Expert Opinion on Investigational Drugs. Jun;11(6):769-86.
Microcapsules as a novel alternative for systemic in vivo delivery of virus vectors
Saller, R.M., Stange J., Mitzner, S., von Rombs, K., Hutzler, P., Dautzenberg, H., Günzburg, W.H. and Salmons, B. (2000) Microcapsules as a novel alternative for systemic in vivo delivery of virus vectors. Minerva Biotecnologica 12, 305-308
Encapsulated antibody-producing cells for long-term passive immunotherapy
Pelegrin, M., Noel, D., Saller, R.M., Salmons, B. and Piechaczyk, M. (1999) Encapsulated antibody-producing cells for long-term passive immunotherapy. Pharmaceutical Technology 23, 46-49 (also BioPharm 12, 32-35)
Characterization of a Human Cell Clone Expressing Cytochrome P450 for Safe Use in Human Somatic Cell Therapy
In vivo production of therapeutic antibodies by engineered cells for immunotherapy of cancer and viral diseases
Pelegrin, M., Noel, D., Marin, M., Bachrach, E., Saller, R.M., Salmons, B. and Piechaczyk, M. (1999) In vivo production of therapeutic antibodies by engineered cells for immunotherapy of cancer and viral diseases. Gene Ther. Mol. Biol. 3, 167-177
Systemic long-term delivery of antibodies in immunocompetent animals using cellulose sulphate capsules containing antibody-producing cells
Pelegrin, M., Marin, M., Noël, D., Del Rio, M., Saller, R., Stange, J., Mitzner, S., Günzburg, W.H. and Piechaczyk, M. (1998) Systemic long-term delivery of antibodies in immunocompetent animals using cellulose sulphate capsules containing antibody-producing cells. Gene Therapy 5, 828-834
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