Cell-in-a-Box allows living cells to grow up within the capsule and then protects them from rejection by the immune system, as well as from cell loss over time, after injection into humans or animals. Cell-in-a-Box encapsulated cells can be frozen and stored at -80oC
The pores are small enough to keep the immune system out, allowing allogenic and xenogeneic cells to be safely transplanted without rejection
Any living cell can be encapsulated to provide them with a micro-environment in which to grow. Small molecules can diffuse in and out through the porous capsule
Cell-in-a-Box encapsulated cells can be manufactured under GMP and supplied in pre-filled syringes or vials for easy administration


Austrianova is a B2B company that offers a living cell bioencapsulation technology called Cell-in-the-Box® that has proven safe and efficacious in clinical trials. Your company sends your cells to us, we encapsulate them either at research or GMP grade and send them back to you. Our living cell encapsulation technology encloses your cells in porous beads made of biocompatible, biologically inert, cellulose sulphate polymers. Upon implantation into the body, it holds cells at the site where needed and protects them from immune rejection and other clearance mechanisms so that less cells are needed to obtain a therapeutic effect. In bioreactors, it protects and shields sensitive cells from shear forces and harsh environments. Cell-in-the-Box® encapsulated cells can be stored for years at -80oC without appreciable loss in viability. Cell-in-the-Box® can be delivered on dry ice worldwide.

Why “Cell-in-a-Box”?

This “Cell-in-a-Box” technology has applications in a number of scenarios such as
1) allowing allogeneic or even xenogeneic encapsulated cells to be implanted in patients without immune rejection in cell therapy treatments where the cells constantly produce therapeutic biomolecules such as enzymes, growth factors, cytokines, hormones, antibodies and even exosomes in vivo. Safety and efficacy of encapsulated cells implanted into patients has already been demonstrated in clinical trials

2) allowing cell amplification within the capsules in bioreactors by making a protected microenvironment for growth and by shielding the cells from shear forces. This is especially useful for fragile cells such as stem cells
3) allowing freezing and storage of encapsulated cells at -80oC for more than five years and then revival with high viability. During this period cells can also be easily transported on dry ice.

Cell-in-the-Box® can be used for research purposes but also as a cell protective implantation device for the treatment of a wide variety of diseases as diverse as cancer, diabetes, cardiovascular and neurodegenerative diseases, enzyme deficiencies and other metabolic diseases.

Austrianova also provides a full service for Cell-in-a-Box cell-based products from conception, cloning, through generation and characterization of cell lines, to production of material for pre-clinical and of GMP production for clinical trials. We offer all this at highly competitive prices and at international quality standards.