Publications

Bacteria Encapsulation

Cell Encapsulation

Our company’s bio-encapsulation technology and its applications have been published in numerous peer-reviewed, well-respected scientific journals. To access the articles for further information, please click on the links below.

All articles are linked to original article or PubMed where available.

If you are interested in re-prints of any articles, please contact pr@austrianova.com with the details.


Salmons, B., Brandtner, E-M., Dangerfield, J.A. and Gunzburg, W.H. (2014) Encapsulation of insulin producing cells for diabetes treatment using alginate and cellulose sulphate as bioencapsulation polymers: current status . Diabetes Research and Treatment 1, 1-7.

Löhr, J. M.; Haas, Stephan L.; Kröger, Jens C.; Friess, Helmut M.; Höft, Raimund; Goretzki, Peter E.; Peschel, C.; Schweigert, M.; Salmons, B.; Gunzburg, W. H. (2014). Encapsulated Cells Expressing a Chemotherapeutic Activating Enzyme Allow the Targeting of Subtoxic Chemotherapy and Are Safe and Efficacious: Data from Two Clinical Trials in Pancreatic Cancer . Pharmaceutics 6, no. 3: 447-466.

Michałowska M, Winiarczyk S, Adaszek Ł, Łopuszyński W, Gradzki Z, et al. (2014) Phase I/II Clinical Trial of Encapsulated, Cytochrome P450 Expressing Cells as Local Activators of Cyclophosphamide to Treat Spontaneous Canine Tumours. PLoS ONE 9(7): e102061. doi:10.1371/journal.pone.0102061

Salmons, B., Dangerfield, J., Tan, W.J., Toa, P., Pawa, R., Aung, M.M., Read, E., Gunzburg, W.H., (2014) Localisation of stem cell and other cell therapies using cell-in-a-box™ for microenvironment containment in patients: a clinically proven enabling cell encapsulation technology. Cytotherapy, Vol. 16, Issue 4, April 2014, page S37.

Dangerfield, J.A., Salmons, B., Corteling, R., Abastado, J-P., Sinden, J., Gunzburg, W.H. and Brandtner, E.M., (2013) Chapter 3: The Diversity of Uses for Cellulose Sulphate Encapsulation. in E-Book: “Bioencapsulation of living cells for diverse medical applications”, Brandtner E.M., Dangerfield J.A. (Eds.), Bentham Science Publishers, June 2013, pages 70-92.

Brandtner, E.M., Muendlein, A., Salmons, B. and H. Drexel. (2012) Inselzellen vor dem Immunangriff schuetzen. 40. Jahrestagung der Oesterreichischen Diabetes Gesellschaft, November 2012, pages 6-7.

Salmons, B. and Gunzburg, W.H.(2012) Suicide gene for cancer therapy. BioSpectrum Asia Ed., Vol. 7, Issue 15, August 15, pages 15-19.

Hlavaty J., Petznek H., Holzmueller H., Url A., Jandl G., Berger, A., Salmons, B., Gunzburg, W.H., and M., Renner (2012) Evaluation of a Gene-Directed Enzyme-Product Therapy (GDEPT) in Human Pancreatic Tumor Cells and Their Use as In Vivo Models for Pancreatic Cancer . PLoS One, July 16;7(7):1-9.e40611. doi:10.1371/journal.pone.0040611

Ortner, V., Kaspar, C., Halter, C. Toellner, L., Mykhaylyk, O., Walzer, J., Gunzburg, W.H., Dangerfield, J.A., Hohenadl, C. T. Czerny, (2010) Magnetic field-controlled gene expression in encapsulated cells . Journal of Controlled Release, Mar 28;158(3):424-32.

Chua, A.J.S., Brandtner, E.M., Dangerfield, J.A., Salmons, B., Gunzburg, W.H. and Ng, M.L. (2010) A novel cell encapsulation mode for delivery of therapeutic antibodies against West Nile Virus infections that maintains steady plasma antibody levels throughout therapy . International Congress on Infectious Diseases (ICID): Abstract 24.010. doi:10.1016/jijid.2010.02

Salmons, B., Dangerfield, J.A., Brandtner, E.M., Toa, P., Tan, W Jin and Gunzburg, W.H. (2010) A method for protecting therapeutic cells and microenvironment containment in patients for gene and cell therapies: a clinically proven enabling cell encapsulation technology . Human Gene Therapy 21 1476-1477

Salmons, B., Brandtner, E.M., Hettrich, K. Wagenknecht, W., Volkert, B., Fischer, S., Dangerfield, J.A. and Gunzburg,W.H. (2010) Encapsulated cells to focus the metabolic activation of anti-cancer drugs . Current Opinion in Molecular Therapeutics 12(4):450-60

Salmons, B. and Gunzburg, W.H. (2010) Therapeutic application of cell microencapsulation in cancer . Advances in Experimental Medicine and biology 670, 92-103.

Lear, M.J., Salmons, B., Gunzburg, W.H., and Dangerfield, J. (2009) Singapore R&D and globetrotting . Biotechnology Journal 4, 179-85

Gunzburg, W.H. and Salmons, B. (2009) Stem cell therapies: on track but suffer setback. Current Opinion in Molecular Therapeutics 11, 360-363

Salmons, B. and Gunzburg, W.H. (2009) Therapeutic application of cell microencapsulation in cancer . In: Therapeutic Applications of Cell Microencapsulation. Eds: J.L. Pedraz and G. Orive. Landes Bioscience publishing. in press

Salmons, B., Hauser, O., Gunzburg W.H. and Tabotta W. (2009) Cell microencapsulation in cancer therapy. In: The bioartificial pancreas and other biohybrid therapies. Eds: Pierre Hallè, Paul de Vos and Lawrence Rosenberg. Research Signpost publishing. pp595-606

Stiegler, P., Stadlbauer, V., Hackl, F., Iberer F., Lackner, C., Hauser, O., Schaffellner, S., Strunk, D., Tscheliessnigg, K.H. (2009) Xenotransplantation of NaCS microencapsulated porcine islet cells in diabetic rats. Organ Biology, 16(1) : 104

Salmons, B., Hauser, O., Gunzburg, W.H. and Tabotta, W. (2007) GMP production of an encapsulated cell therapy product: issues and considerations . BioProcessing Journal 4, 36-43

Samel, S. and Löhr, M. (2007) Targeted intra-abdominal chemotherapy for peritoneal carcinomatosis . Cancer Treatment and Research 134, 469-82

Samel, S., Keese, M., Lux, A., Jesnowski, R., Prosst, R., Saller, R., Hafner, M., Sturm, J., Post, S. and Löhr, M. (2006) Peritoneal cancer treatment with CYP2B1 transfected, microencapsulated cells and ifosfamide . Cancer Gene Therapy. 13, 65-73

Stadlbauer, V., Stiegler, P.B., Schaffellner, S., Hauser, O., Halwachs, G., Iberer, F., Tscheliessnigg, K.H. and Lackner, C. (2006) Morphological and functional characterization of a pancreatic beta-cell line microencapsulated in sodium cellulose sulfate/poly(diallyldimethylammonium chloride). Xenotransplantation 13, 337-344

Stiegler, P.B., Stadlbauer, V., Schaffellner, S., Halwachs, G., Lackner, C., Hauser, O., Iberer, F. and Tscheliessnigg, K. (2006) Cryopreservation of insulin-producing cells microencapsulated in sodium cellulose sulfate . Transplantation Procedures 38, 3026-30

Schaffellner, S., Stadlbauer, V., Stiegler, P., Hauser, O., Halwachs, G., Lackner, C., Iberer, F. and Tscheliessnigg, K.H. (2005) Porcine islet cells microencapsulated in sodium cellulose sulfate. Transplantation Procedures 37, 248-452

Ryschich, E., Jesnowski, R., Ringel, J., Harms, W., Fabian, O.V., Saller, R., Schrewe, M., Engel, A., Schmidt, J. and Löhr, M. (2005) Combined therapy of experimental pancreatic cancer with CYP2B1 producing cells: low-dose ifosfamide and local tumor irradiation . International Journal of Cancer 113, 649-53

Gunzburg, W.H. and Salmons, B. (2005) Cell and gene therapy to improve cancer treatment. Acta Biochimica Polonica 52, 601-607

Hauser, O., Prieschl-Grassauer, E. and Salmons, B. (2004) Encapsulated, genetically modified, cells producing in vivo therapeutics . Current Opinion in Molecular Therapeutics 6, 412-420

Löhr, M., Hummel, F. Gunzburg, W.H. and Salmons, B. (2003) Experimental treatment of pancreatic cancer. Disease Progression and Carcinogenesis in the Gastrointestinal Tract . Eds. Galle,†P.R., Gerken, G.,†Schmidt,†W.E. and† Wiedenmann, B. Kluwer Academic Publishers, Dordrecht, The Netherlands

Löhr, M., Hain, J., Gunzburg, W.H., Salmons, B. and Saller, R. (2003) Gene therapy in pancreatic cancer. Controversies in Pancreatology, Permet, J., Herrington, M. and Adrian, T.E. Pancreas 2000 publishing. pp102-110

Löhr, J.M., Kröger, J-C., Hoffmeyer, A., Freund, M., Hain, J., Holle, A., Knöfel, W.T., Liebe, S., Nizze, H., Renner, M., Saller, R., Karle, P., Müller, P., Wagner, T., Hauenstein, K., Salmons, B. and Gunzburg, W.H. (2003) Safety, feasibility and clinical benefit of localized chemotherapy using microencapsulated cells for inoperable pancreatic carcinoma in a phase I/II trial. Cancer Therapy 1, 121-131

Uckert, W., Salmons, B., Beltinger, C., Gunzburg, W.H. and Kammertöns, T. (2003) Combination suicide gene therapy . Methods in Molecular Medicine 90, 345-35

Kröger, J-C., Benz, S., Hoffmeyer, A., Bago, Z., Bergmeister, H., Gunzburg, W.H., Karle, P., Klöppel, G., Losert, U., Müller, P., Nizze, H., Obermaier, R., Probst, A., Renner, M., Saller, R., Salmons, B., Schwendenwein, I., von Rombs, K., Wiessner, R., Wagner, T., Hauenstein, K. and Löhr, M. (2003) Intra-arterial Instillation of microencapsulated, ifosfamide activating cells in the pig pancreas for chemotherapeutic targeting. Pancreatology 3, 55-63

Salmons, B., Löhr, M. and Gunzburg, W.H. (2003) Treatment of inoperable pancreatic carcinoma using a cell based local chemotherapy: results of a phase I/II clinical trial. Journal of Gastroenterology 38 (Suppl XV), 78-84

Winiarczyk, S., Gradski, Z., Kosztolich, B., König, G., Gunzburg, W.H., Salmons, B. and J. Hain (2002) A clinical protocol for treatment of canine mammary tumors using encapsulated cytochrome P450 synthesizing cells activating cyclophosphamide: A phase I/II study . Journal of molecular Medicine 80, 610-614

Lohr, M., Hummel, F., Faulmann, G., Ringel, J., Saller, R., Hain, J., Gunzburg, W.H. and Salmons, B. (2002) Microencapsulated, CYP2B1-transfected cells activating ifosfamide at the site of the tumor: the magic bullets of the 21st century. Cancer Chemotherapy and Pharmacology 49, suppl.1 21-24

Saller, R.M., Indraccolo, S., Coppola, V., Esposito, G., Stange, J., Mitzner, S., Heinzmann, U., Amadori, A., Salmons, B. and Gunzburg, W.H. (2002) Encapsulated cells producing retroviral vectors for in vivo gene transfer . Journal of Gene Medicine 4, 150-160

Löhr, M., Saller, R.M., Salmons, B. and Gunzburg, W.H. (2002) . Microencapsulation of genetically engineered cells for cancer therapy. Methods in Enzymology 346, 603-618

Gunzburg WH, Löhr M, Salmons B. (2002) Novel treatments and therapies in development for pancreatic cancer. Expert Opinion on Investigational Drugs. Jun;11(6):769-86.

Armeanu, S., Haessler, I., Saller, R., Engelmann, M.G., Heinemann, F., Krausz, E., Stange, J., Mitzner, S., Salmons, B., Gunzburg, W.H. and Nikol, S. (2001) In vivo perivascular implantation of encapsulated packaging cells for prolonged retroviral gene transfer. Journal of Microencapsulation 18, 491-506

Löhr, J.M., Hoffmeyer, A., Kröger, J-C., Freund, M., Hain, J., Holle, A., Karle, P., Knöfel, W.T., Liebe, S., Müller, P., Nizze, H., Renner, M., Saller, R.M., Wagner, T., Hauenstein, K. Gunzburg, W.H., and Salmons, B. (2001) Microencapsulated cell mediated therapy of inoperable pancreatic carcinoma. Lancet 357, 1591-1592

Gunzburg, W.H., Renner, M. and Salmons, B. (2000) New strategies for the gene therapy of solid and metastatic tumours. Annales Universitatis Mariae Curie-Sklodowska: Sectio DD Medicina Veterinaria vol. LV/A pp9-14

Saller, R.M., Stange J., Mitzner, S., von Rombs, K., Hutzler, P., Dautzenberg, H., Gunzburg, W.H. and Salmons, B. (2000) Microcapsules as a novel alternative for systemic in vivo delivery of virus vectors. Minerva Biotecnologica 12, 305-308

Pelegrin, M., Marin, M., Oates, A., NoÎl, D., Saller, R., Salmons, B. and Piechaczyk, M. (2000) Immunotherapy of a viral disease by in vivo production of therapeutic monoclonal antibodies. Human Gene Therapy 11, 1407-1416

Kammertöns, T., Gelbmann, W., Karle, P., Saller, R., Salmons, B., Gunzburg, W.H. and Uckert, W. (2000) Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine . Cancer Gene Therapy 7, 629-636

Pelegrin, M., Noel, D., Saller, R.M., Salmons, B. and Piechaczyk, M. (1999) Encapsulated antibody-producing cells for long-term passive immunotherapy . Pharmaceutical Technology 23, 46-49 (also BioPharm 12, 32-35)

Muller, P., Jesnowski, R., Karle, P., Renz, R., Saller, R., Stein, H., Puschel, K., von Rombs, K., Nizze, H., Liebe, S., Wagner, T., Gunzburg, W.H., Salmons, B., Lohr, M. (1999) Injection of encapsulated cells producing an ifosfamide-activating cytochrome P450 for targeted chemotherapy to pancreatic tumors. Annals of New York Academy of Science 880, 337-351

Kröger, J.C., Bergmeister, H., Hoffmeyer, A., Ceijna, M., Karle, P., Saller, R., Schwendenwein, I., von Rombs, K., Liebe, S., Gunzburg, W.H., Salmons, B., Hauenstein, K-H., Losert, U. and Löhr, M. (1999) Intra-arterial instillation of microencapsulated cells in the pancreatic arteries in pig. Annu. N. Y. Acad. Sci. 880, 374-378

Gunzburg, W.H., Karle, P., Renz, R., Salmons, B. and Renner, M. (1999) Characterisation of a human cell clone expressing cytochrome P450 for safe use in human somatic cell therapy . Annu. N. Y. Acad. Sci. 880, 326-336

Löhr, J.M., Bago, Z.T., Bergmeister, H., Ceijka, M., Freund, M., Gelbmann, W., Gunzburg, W.H., Hain, J., Hauenstein, K., Henniger, W., Hoffmeyer, A., Karle, P., Kröger, J-C., Liebe, S., Losert, U., Probst, A., Renner, M., Renz, R., Saller, R., Salmons, B., Schuh, M., Wagner, T. and Walter, I. (1999) Cell therapy using microencapsulated 293 cells transfected with a gene construct expressing CYP2B1, an ifosfamide converting enzyme, instilled intra-arterially in patients with advanced stage pancreatic carcinoma: phase I/II study. Journal of Molecular Medicine. 77, 393-398

Dautzenberg, H., Schuldt, U., Grasnick, G., Karle, P., Müller, P., Löhr, M., Pelegrin, M., Piechaczyk, M., von Rombs, K., Gunzburg, W.H., Salmons, B. and Saller, R.M. (1999) Development of cellulose sulphate based polyelectrolyte complex microcapsules for medical applications. (Bioartificial Organs II: Technology, Medicine & Materials. Eds. Hunkeler, D., Prokop, A., Cherrrington, A.D., Rajotte, R. and Sefton, M.) Annu. N.Y. Acad. Sci. 875, 46-63

Pelegrin, M., Noel, D., Marin, M., Bachrach, E., Saller, R.M., Salmons, B. and Piechaczyk, M. (1999) In vivo production of therapeutic antibodies by engineered cells for immunotherapy of cancer and viral diseases. Gene Ther. Mol. Biol. 3, 167-177

Pelegrin, M., Marin, M., NoÎl, D., Del Rio, M., Saller, R., Stange, J., Mitzner, S., Gunzburg, W.H. and Piechaczyk, M. (1998) Systemic long-term delivery of antibodies in immunocompetent animals using cellulose sulphate capsules containing antibody-producing cells. Gene Therapy 5, 828-834

Karle, P., Müller, P., Renz, R., Jesnowski, R., Saller, R.M., von Rombs, K., Nizze, H., Liebe, S., Gunzburg, W.H., Salmons, B and Löhr, M. (1998) Intratumour injection of encapsulated cells producing an ifosfamide activating cytochrome P450 for targeted chemotherapy . Adv. Exp. Med. Biol. 451, 97-106

Löhr, M., Müller, P., Karle, P., Stange, J., Mitzner, S., Jesnowski, R., Nizze, H., Nebe, B., Liebe, S., Salmons, B. and Gunzburg, W.H. (1998) Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450. Gene Therapy 5, 1070-1078